Phenotypes Associated with This Genotype

Genotype
MGI:5806112

• Allelic Composition: Foxg1^tm1(cre)Skm/Foxg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal visual evoked potential ( J:235875 )

• visually evoked potential amplitudes at low spatial frequency are strongly diminished

• however, no changes in general organization, architecture and pattern or lamination of retina are seen

decreased visual acuity ( J:235875 )

• cortical visual acuity is reduced at P30

nervous system

abnormal cerebral cortex pyramidal cell morphology ( J:235875 )

• decrease in spine density, but not spine length, in the basal dendrites of pyramidal cells (layer 2/3) in visual cortices

abnormal visual cortex morphology ( J:235875 )

• the visual cortex is thinner, with specific layer II-III and layer IV reduction

• increase in interneuron density and a reduction of parvalbumin-positive cell density in layers II-III and VI of the visual cortex

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:235875