endocrine/exocrine glands
• expansion of the pancreatic stroma
|
• mice show extensive intraductal papillary neoplasm development and associated parenchymal loss
|
• pancreatic lesions are accompanied with more severe fibrosis and heavy matrix deposition
|
• mice develop pancreatic acinar-to-ductal metaplasia
|
• increase in proliferating cell nuclear antigen (PCNA) staining throughout the entire pancreas
|
• mice display marked pancreatic inflammation
|
hematopoietic system
• total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration
|
immune system
• mice display marked pancreatic inflammation
|
• total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration
|
neoplasm
• mice show extensive intraductal papillary neoplasm development and associated parenchymal loss
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
pancreatic carcinoma | DOID:4905 |
OMIM:260350 |
J:231759 |