Phenotypes Associated with This Genotype

Genotype
MGI:5806507

• Allelic Composition: Tg(SFTPC-SDC4/ROS1)141Tno/0
• Genetic Background: C57BL/6J-Tg(SFTPC-SDC4/ROS1)141Tno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:231770 )

• all mice die by 50 weeks of age

neoplasm

increased lung tumor incidence ( J:231770 )

• lepidic growth of the alveolar walls and papillary nodules are seen as early as 2.1 weeks of age

• multiple nodules are seen in the lungs and mice show rapid tumor progression

• mice treated with crizotinib or ASP3026 show reduced tumor burden, reduced thickness of alveolar walls and suppression of tumor nodules

increased lung adenoma incidence ( J:231770 )

• mice show development of multiple lung adenoma

increased lung non-small cell carcinoma incidence ( J:231770 )

• lung tumors show similarity to human ROS1-fusion non-small cell lung cancer

increased lung adenocarcinoma incidence ( J:231770 )

• mice show development of adenocarcinoma-like nodules and lepidic lesions

respiratory system

increased lung tumor incidence ( J:231770 )

• lepidic growth of the alveolar walls and papillary nodules are seen as early as 2.1 weeks of age

• multiple nodules are seen in the lungs and mice show rapid tumor progression

• mice treated with crizotinib or ASP3026 show reduced tumor burden, reduced thickness of alveolar walls and suppression of tumor nodules

increased lung adenoma incidence ( J:231770 )

• mice show development of multiple lung adenoma

increased lung non-small cell carcinoma incidence ( J:231770 )

• lung tumors show similarity to human ROS1-fusion non-small cell lung cancer

increased lung adenocarcinoma incidence ( J:231770 )

• mice show development of adenocarcinoma-like nodules and lepidic lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:231770