mortality/aging
• mice withdrawn from tetracycline and treated with polyinosine-polycyticylic acid (pIpC) show a decrease in survival with median survival of 116.5 days
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neoplasm
• majority of pIpC treated mice (85%) develop an exclusively myeloid and primary acute leukemia phenotype
• 5% of mice remain in the chronic phase of the disease
• about 10% of mice develop an accelerated phase-like phenotype but with less than 20% blasts
• however, mice do not develop lymphoid leukemias
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hematopoietic system
• in pIpC treated mice
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• hemoglobin levels are decreased in pIpC treated mice
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• upon withdrawal of tetracycline and treatment with pIpC, mice develop moderate, but persistent (2-3 fold) increase of white blood counts
• white blood cell counts at the terminal endpoint are elevated, indicating a dramatic preterminal proliferative change in kinetics of their disease
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• upon withdrawal of tetracycline and treatment with pIpC, mice show marked expansion of the granulocyte compartment
• increase in infiltration of tissues with both granulocytes and immature cells
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• disease progression in in pIpC treated mice is frequently accompanied by an increase in basophils
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• the myeloid progenitor compartment is expanded in pIpC treated mice, including the granulocyte monocyte progenitor compartment
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• expansion of the lineage-negative (Lin-) bone marrow fraction in pIpC treated mice
• however, no differences are seen in total Lin-Sca+c-kit+ (LSK) numbers, long-term and short-term hematopoietic stem cell or multipotent progenitor proportions
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• hematopoietic stem cells show an increased ability to serially replate compared to control cells
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immune system
• in pIpC treated mice
|
• upon withdrawal of tetracycline and treatment with pIpC, mice develop moderate, but persistent (2-3 fold) increase of white blood counts
• white blood cell counts at the terminal endpoint are elevated, indicating a dramatic preterminal proliferative change in kinetics of their disease
|
• upon withdrawal of tetracycline and treatment with pIpC, mice show marked expansion of the granulocyte compartment
• increase in infiltration of tissues with both granulocytes and immature cells
|
• disease progression in in pIpC treated mice is frequently accompanied by an increase in basophils
|
liver/biliary system
• in pIpC treated mice
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growth/size/body
• in pIpC treated mice
|
• in pIpC treated mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
chronic myeloid leukemia | DOID:8552 |
OMIM:608232 |
J:227558 |