Phenotypes Associated with This Genotype

Genotype
MGI:5806789

• Allelic Composition: Tg(Thy1-SNCA*E57K)16Ema/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal habituation to a new environment ( J:236596 )

• 3-4 month old mice show a trend towards continued high activity and failure to habituate to a novel environment, indicating impaired learning

• 8-10 month old mice fail to habituate to a novel environment

nervous system

astrocytosis ( J:236596 )

• increase in GFAP immunoreactivity in the neocortex and hippocampus, indicating astrogliosis

abnormal dendrite morphology ( J:236596 )

• dendritic loss in the CA2-3 region of the hippocampus

abnormal synapse morphology ( J:236596 )

• synaptic accumulation of electro-dense bodies

• enlarged nerve terminals that display distended vesicles

• synapto-dendritic loss in the frontal cortex and hippocampus

abnormal synaptic vesicle number ( J:236596 )

• reduction in the numbers of synaptic vesicles in the nerve terminals

alpha-synuclein inclusion body ( J:236596 )

• mice show abundant oligomeric, but not fibrillary, alpha synuclein

• -alpha-synuclein accumulates in the synapses but not in the neuronal cell bodies

neurodegeneration ( J:236596 )

• neurodegeneration in the frontal cortex and hippocampus

• however, no changes in neuronal population in the striatum are seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Lewy body dementia		DOID:12217	OMIM:127750	J:236596
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:236596