Phenotypes Associated with This Genotype

Genotype
MGI:5810684

• Allelic Composition: Tg(Hsf4/EGFP)N7Spbh/0
• Genetic Background: C57BL/6-Tg(Hsf4/EGFP)N7Spbh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:230205 )

• weight of lens at 5 months of age is decreased about 25%

abnormal lens epithelium morphology ( J:230205 )

• number of epithelial cells is increased in lenses

abnormal lens fiber morphology ( J:230205 )

• the number of total fiber cell nuclei (an indicator of differentiation) is decreased in the lens of founder mice, however, the number of fiber cell nuclei is increased in F2 mice

• mice show different degrees of disturbances in the bow region, with nuclei seen even in the posterior of the lens

lamellar cataract ( J:230205 )

• mice show bilateral nuclear opacities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 5 multiple types		DOID:0110255	OMIM:116800	J:230205