Phenotypes Associated with This Genotype

Genotype
MGI:5811262

• Allelic Composition: Kit^W-v/Kit^W-v; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased ovary tumor incidence ( J:236161 )

• mice injected with an adenovirus-expressing Cre recombinase (Ad-Cre) into the ovarian bursa at 2 months of age exhibit enhanced growth of ovarian tumors compared to single homozygous Kit mutants, however, no metastasis or spreading of the tubular adenomas is seen in most mice

• tumors in Ad-Cre injected mice are largely epithelial in origin and similar to human serous ovarian cancer

• 3 of 12 mice injected with Ad-Cre into the ovarian bursa develop aggressive tumors

endocrine/exocrine glands

increased ovary tumor incidence ( J:236161 )

• mice injected with an adenovirus-expressing Cre recombinase (Ad-Cre) into the ovarian bursa at 2 months of age exhibit enhanced growth of ovarian tumors compared to single homozygous Kit mutants, however, no metastasis or spreading of the tubular adenomas is seen in most mice

• tumors in Ad-Cre injected mice are largely epithelial in origin and similar to human serous ovarian cancer

• 3 of 12 mice injected with Ad-Cre into the ovarian bursa develop aggressive tumors

ovary cyst ( J:236161 )

• mice injected with Ad-Cre into the ovarian bursa show ovaries that commonly contain cysts of hemorrhage appearance

abnormal ovary physiology ( J:236161 )

• ovarian epithelial cells show enhanced cell proliferation in culture compared to single homozygous Kit mutants

reproductive system

increased ovary tumor incidence ( J:236161 )

• mice injected with an adenovirus-expressing Cre recombinase (Ad-Cre) into the ovarian bursa at 2 months of age exhibit enhanced growth of ovarian tumors compared to single homozygous Kit mutants, however, no metastasis or spreading of the tubular adenomas is seen in most mice

• tumors in Ad-Cre injected mice are largely epithelial in origin and similar to human serous ovarian cancer

• 3 of 12 mice injected with Ad-Cre into the ovarian bursa develop aggressive tumors

ovary cyst ( J:236161 )

• mice injected with Ad-Cre into the ovarian bursa show ovaries that commonly contain cysts of hemorrhage appearance

abnormal ovary physiology ( J:236161 )

• ovarian epithelial cells show enhanced cell proliferation in culture compared to single homozygous Kit mutants

growth/size/body

ovary cyst ( J:236161 )

• mice injected with Ad-Cre into the ovarian bursa show ovaries that commonly contain cysts of hemorrhage appearance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:236161