craniofacial
• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
|
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
growth/size/body
• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
|
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
nervous system
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
• structure of the olfactory bulb is altered
|
• the glomerular layer is thinner, with a massive loss of glomeruli
• treatment with doxycycline restores the glomerular layer, although the glomerular layer appears disorganized
|
• outer nerve layer is thinner
• increase in apoptosis in the outer nerve layer
• treatment with doxycycline restores the outer nerve layer
|
• reduction in size of the olfactory bulb
|
• mice show a reduction in VGlu2 staining, indicating loss of olfactory sensory neuron axon terminals in the olfactory bulb
• treatment with doxycycline restores these axon terminals in the olfactory bulb
|
• treatment with doxycycline reverses neurodegeneration
• neurodegeneration of olfactory sensory neurons, with most lost between 7 and 14 days of age
|
• rapid and widespread apoptosis in mature olfactory sensory neurons
|
respiratory system
• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
|
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
• rapid and widespread apoptosis in mature olfactory sensory neurons
|
taste/olfaction
• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
|
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
|
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
|
• rapid and widespread apoptosis in mature olfactory sensory neurons
|
• in a buried food assay, mice take a longer time to find the cookie
• in an avoidance assay in which the simple odorant isovaleric acid is added to drinking water and becomes an aversive stimulus associated with an LiCl injection, the conditioned mutants show a higher preference for the odor-water than controls, indicating decreased ability to detect the odor
• administration of doxycycline restores odor detection in both the buried food assay and at high concentration of isovaleric acid in the avoidance assay
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Alzheimer's disease | DOID:10652 | J:199798 |