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Phenotypes Associated with This Genotype
Genotype
MGI:5811870
Allelic
Composition
Omptm1(tTA)Gogo/Omp+
Tg(tetO-APPSwInd)Dbo/0
Genetic
Background
involves: 129 * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Tg(tetO-APPSwInd)Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal

growth/size/body
• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal

nervous system
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
• structure of the olfactory bulb is altered
• the glomerular layer is thinner, with a massive loss of glomeruli
• treatment with doxycycline restores the glomerular layer, although the glomerular layer appears disorganized
• outer nerve layer is thinner
• increase in apoptosis in the outer nerve layer
• treatment with doxycycline restores the outer nerve layer
• reduction in size of the olfactory bulb
• mice show a reduction in VGlu2 staining, indicating loss of olfactory sensory neuron axon terminals in the olfactory bulb
• treatment with doxycycline restores these axon terminals in the olfactory bulb
• treatment with doxycycline reverses neurodegeneration
• neurodegeneration of olfactory sensory neurons, with most lost between 7 and 14 days of age
• rapid and widespread apoptosis in mature olfactory sensory neurons

respiratory system
• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
• rapid and widespread apoptosis in mature olfactory sensory neurons

taste/olfaction
• olfactory epithelium is thinner in 3 week old mice
• olfactory epithelium shows fewer dendritic knobs with fewer cilia
• axonal degeneration of olfactory sensory neurons
• treatment with doxycycline prevents axonal degeneration
• mature olfactory sensory neuron population is reduced in 3 week old mice
• however, the immature sensory neuron population is normal
• rapid and widespread apoptosis in mature olfactory sensory neurons
• in a buried food assay, mice take a longer time to find the cookie
• in an avoidance assay in which the simple odorant isovaleric acid is added to drinking water and becomes an aversive stimulus associated with an LiCl injection, the conditioned mutants show a higher preference for the odor-water than controls, indicating decreased ability to detect the odor
• administration of doxycycline restores odor detection in both the buried food assay and at high concentration of isovaleric acid in the avoidance assay

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:199798


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory