Phenotypes Associated with This Genotype

Genotype
MGI:5811870

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

growth/size/body

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

nervous system

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory bulb morphology ( J:199798 )

• structure of the olfactory bulb is altered

abnormal olfactory bulb glomerular layer morphology ( J:199798 )

• the glomerular layer is thinner, with a massive loss of glomeruli

• treatment with doxycycline restores the glomerular layer, although the glomerular layer appears disorganized

abnormal olfactory bulb outer nerve layer morphology ( J:199798 )

• outer nerve layer is thinner

• increase in apoptosis in the outer nerve layer

• treatment with doxycycline restores the outer nerve layer

small olfactory bulb ( J:199798 )

• reduction in size of the olfactory bulb

abnormal synaptic bouton morphology ( J:199798 )

• mice show a reduction in VGlu2 staining, indicating loss of olfactory sensory neuron axon terminals in the olfactory bulb

• treatment with doxycycline restores these axon terminals in the olfactory bulb

neurodegeneration ( J:176127 )

• neurodegeneration of olfactory sensory neurons, with most lost between 7 and 14 days of age

• treatment with doxycycline reverses neurodegeneration

abnormal olfactory sensory neuron physiology ( J:176127 )

• rapid and widespread apoptosis in mature olfactory sensory neurons

respiratory system

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory sensory neuron physiology ( J:176127 )

• rapid and widespread apoptosis in mature olfactory sensory neurons

taste/olfaction

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory sensory neuron physiology ( J:176127 )

• rapid and widespread apoptosis in mature olfactory sensory neurons

impaired olfaction ( J:199798 )

• in a buried food assay, mice take a longer time to find the cookie

• in an avoidance assay in which the simple odorant isovaleric acid is added to drinking water and becomes an aversive stimulus associated with an LiCl injection, the conditioned mutants show a higher preference for the odor-water than controls, indicating decreased ability to detect the odor

• administration of doxycycline restores odor detection in both the buried food assay and at high concentration of isovaleric acid in the avoidance assay

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:199798