Analysis Tools
nervous system
microgliosis
(
J:236737
)
|
• activated microglia encapsulate amyloid beta plaques
• increase in the density of microglia surrounding plaques
|
|
• mice show moderate and severe plaque burden at 6 and 11 months of age, respectively
• amyloid beta plaques displace neurons and axon initial segments such that axon initial segments frequently bend or take circuitous trajectories around, but seldom through, amyloid beta plaques
|
|
• hypertrophic astrocytes are seen in the vicinity of plaques
|
|
• occasionally axon initial segments traverse or are at the edges of plaques; these axon initial segments are fragmented, shorter, and thinner than those further away from the plaque
• decrease in the number of axon initial segments at 6 and 11 months of age
|
|
• brains with heavy plaque burden have axons with random orientations and many dystrophic, degenerating axons, including axonal torpedoes
|
hematopoietic system
microgliosis
(
J:236737
)
|
• activated microglia encapsulate amyloid beta plaques
• increase in the density of microglia surrounding plaques
|
homeostasis/metabolism
|
• mice show moderate and severe plaque burden at 6 and 11 months of age, respectively
• amyloid beta plaques displace neurons and axon initial segments such that axon initial segments frequently bend or take circuitous trajectories around, but seldom through, amyloid beta plaques
|
immune system
microgliosis
(
J:236737
)
|
• activated microglia encapsulate amyloid beta plaques
• increase in the density of microglia surrounding plaques
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:236737 | ||
