Analysis Tools
endocrine/exocrine glands
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• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
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• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced
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• sublingual gland weight is decreased in 7-10-week old mice
• sublingual glands exhibit smaller glandular lobes in 7-10-week old mice
• however, glands show no morphological differences in histology
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• mice show a delay in submandibular gland development
• E12.5 explant culture of submandibular glands show smaller epithelial prebud-like invaginations of the epithelium and this delay in development continues with reduced branching
• at E14.5, the epithelium fails to invade the most aboral part of the mesenchymal capsule in culture
• the epithelium of the mesenchymal capsule of the submandibular gland is less developed at E14.5, with fewer branches, larger epithelial buds and more extensive areas of mesenchyme not invaded by the epithelium
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• submandibular gland and sublingual gland weight is decreased in 7-10-week old mice
• submandibular glands exhibit smaller glandular lobes in 7-10-week old mice
• however, glands show no morphological differences in histology
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|
• the overall size of salivary gland lobes appears smaller and weight is reduced at P14
• males have larger glands compared to females
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• mice show a reduction in saliva flow from both the submandibular gland and parotid gland
• mice show a reduction in the salivary pellicle on the tongue; mice treated with HCl to remove the mucus from the oral surface show complete removal of mucus unlike wild-type mice that show sheets of mucus remaining
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xerostomia
(
J:299375
)
behavior/neurological
polydipsia
(
J:299375
)
craniofacial
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• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva
|
xerostomia
(
J:299375
)
|
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
|
|
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced
|
digestive/alimentary system
|
• sublingual gland weight is decreased in 7-10-week old mice
• sublingual glands exhibit smaller glandular lobes in 7-10-week old mice
• however, glands show no morphological differences in histology
|
|
• mice show a delay in submandibular gland development
• E12.5 explant culture of submandibular glands show smaller epithelial prebud-like invaginations of the epithelium and this delay in development continues with reduced branching
• at E14.5, the epithelium fails to invade the most aboral part of the mesenchymal capsule in culture
• the epithelium of the mesenchymal capsule of the submandibular gland is less developed at E14.5, with fewer branches, larger epithelial buds and more extensive areas of mesenchyme not invaded by the epithelium
|
|
• submandibular gland and sublingual gland weight is decreased in 7-10-week old mice
• submandibular glands exhibit smaller glandular lobes in 7-10-week old mice
• however, glands show no morphological differences in histology
|
|
• the overall size of salivary gland lobes appears smaller and weight is reduced at P14
• males have larger glands compared to females
|
|
• mice show a reduction in saliva flow from both the submandibular gland and parotid gland
• mice show a reduction in the salivary pellicle on the tongue; mice treated with HCl to remove the mucus from the oral surface show complete removal of mucus unlike wild-type mice that show sheets of mucus remaining
|
xerostomia
(
J:299375
)
growth/size/body
|
• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva
|
xerostomia
(
J:299375
)
|
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
|
|
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced
|
homeostasis/metabolism
|
• mice show a reduction in saliva flow from both the submandibular gland and parotid gland
• mice show a reduction in the salivary pellicle on the tongue; mice treated with HCl to remove the mucus from the oral surface show complete removal of mucus unlike wild-type mice that show sheets of mucus remaining
|
xerostomia
(
J:299375
)
respiratory system
|
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
|
|
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced
|
skeleton
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• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| lacrimoauriculodentodigital syndrome 1 | DOID:0050331 |
OMIM:149730 |
J:237227 | |
