Analysis Tools
integument
scaly skin
(
J:236095
)
|
• mice develop scaly skin 4 weeks after tamoxifen treatment
|
muscle
|
• in tamoxifen-treated mice, atomic force (AFM) and scanning electron microscopy (SEM) of tail tendon collagen I revealed swollen and distorted fibrils, lack of cohesion, crimping and disordered fibrils, unlike in control mice where normal D-banding and consistently regular and aligned fibrils are observed
• AFM showed a large increase in height with swelling causing large jumps in profile analysis
• although the fibrillar D-banding period is not significantly altered, localized variations in the shape of the banding are observed, suggesting a disparity in quaternary collagen I structure
|
skeleton
|
• in tamoxifen-treated mice, atomic force (AFM) and scanning electron microscopy (SEM) of tail tendon collagen I revealed swollen and distorted fibrils, lack of cohesion, crimping and disordered fibrils, unlike in control mice where normal D-banding and consistently regular and aligned fibrils are observed
• AFM showed a large increase in height with swelling causing large jumps in profile analysis
• although the fibrillar D-banding period is not significantly altered, localized variations in the shape of the banding are observed, suggesting a disparity in quaternary collagen I structure
|
growth/size/body
| N |
• no visceral abnormalities are observed after tamoxifen treatment
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| ARC syndrome | DOID:0050763 |
OMIM:PS208085 |
J:236095 | |
