Phenotypes Associated with This Genotype

Genotype
MGI:5817650

cn1

• Allelic Composition: Rai1^tm2.1Luo/Rai1^tm2.1Luo; Tg(Sim1-cre)1Lowl/?
• Genetic Background: either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased body fat mass ( J:237687 )

♀

increased total fat pad weight ( J:237687 )

♀ • increased fat pad weight: gonadal, subcutaneous, retroperitoneal, mesenteric and BAT

behavior/neurological

behavior/neurological phenotype ( J:237687 )

♂N • males exhibit no motor weakness in wire hang test

polyphagia ( J:237687 )

♀ • hyperphagic with a 47% increase in average daily food intake

decreased locomotor activity ( J:237687 )

♂ • decreased horizontal locomotor activity

growth/size/body

increased body fat mass ( J:237687 )

♀

increased lean body mass ( J:237687 )

♀

obese ( J:237687 )

♀ • mice are 57% heavier than controls at 20 weeks of age

homeostasis/metabolism

increased cholesterol level ( J:237687 )

♀

increased circulating HDL cholesterol level ( J:237687 )

♀

increased circulating LDL cholesterol level ( J:237687 )

♀

increased circulating VLDL cholesterol level ( J:237687 )

♀

increased triglyceride level ( J:237687 )

♀