Phenotypes Associated with This Genotype

Genotype
MGI:5819052

• Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy; Ldlr^tm1Her/Ldlr^tm1Her; Lep^ob/Lep^ob
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:133453 )

• at 12 weeks of age, atherosclerotic lesions are seen mainly in the aortic region of the whole aorta

• leptin treatment and food restriction results in lower atherosclerotic lesion size

hypertension ( J:133453 )

• elevated blood pressure

• treatment with enalapril corrects the elevated blood pressure

growth/size/body

obese ( J:133453 )

• increase in body weight, with mice weighing about 58 grams at 15-16 weeks of age

homeostasis/metabolism

increased circulating insulin level ( J:133453 )

• mice show increased insulin levels

• however, mice show normal glucose levels and glucose tolerance

• leptin treatment lowers insulin more than food restriction does

abnormal circulating cholesterol level ( J:133453 )

• mice have more LDL than VLDL, with lower HDL levels compared to wild-type mice which have HDL as the dominant lipoprotein species and very low levels of LDL and VLDL

• both leptin treatment and food restriction result in 39.2% and 30% reduction, respectively, of cholesterol levels

decreased circulating HDL cholesterol level ( J:133453 )

• mice have lower HDL levels

increased circulating cholesterol level ( J:133453 )

• cholesterol levels are elevated almost 10-fold compared to wild-type mice

increased circulating LDL cholesterol level ( J:133453 )

• mice have more LDL than VLDL

increased circulating free fatty acids level ( J:133453 )

increased circulating triglyceride level ( J:133453 )

• plasma triglyceride levels are 3-fold higher at 15-16 weeks of age than in wild-type mice

• both leptin treatment and food restriction result in a 32% and 58%, respectively, reduction in circulating triglyceride levels

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
abdominal obesity-metabolic syndrome 1		DOID:14221	OMIM:605552	J:133453