Phenotypes Associated with This Genotype

Genotype
MGI:5819105

• Allelic Composition: Pclo^tm1.1Mver/Pclo^tm1.1Mver
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synaptic transmission ( J:225358 )

• neurons show increased excitatory synaptic transmission

• however, mice show normal neuronal morphology

increased excitatory postsynaptic current amplitude ( J:225358 )

• the EPSC amplitude in nave autaptic hippocampal neurons is 30% higher than in wild-type neurons, while the release kinetics are unaffected

increased synaptic depression ( J:225358 )

• the vesicular release probability is elevated in neurons and mice show faster rundown of EPSC size during high-frequency stimulation indicating increased neurotransmitter release and faster synaptic depression

increased neurotransmitter release ( J:225358 )

• the vesicular release probability is elevated in neurons and mice show faster rundown of EPSC size during high-frequency stimulation indicating increased neurotransmitter release and faster synaptic depression

behavior/neurological

behavior/neurological phenotype ( J:225358 )

N • mice exhibit normal spontaneous behavior in the home cage, avoidance learning in the home cage, anxiety related behavior, cognitive behavior (spatial recognition, learning and memory), sensorimotor gating, fear memory, and depression-like behavior

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	melancholic depression	DOID:1595	OMIM:608516	J:225358