Phenotypes Associated with This Genotype

Genotype
MGI:5824372

cn1

• Allelic Composition: Cdk5r1^tm2Ohsh/Cdk5r1^tm2Ohsh; Tg(Pcp2-cre)1Amc/0
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:215344 )

• mice show a significantly impaired ability to maintain balance on a rotating rod at 3 different speeds (16, 24 and 32 rpm)

• in a balance beam test, mice show a significantly increased number of paw slips at two different beam diameters (11 mm and 28 mm)

• however, no gait disturbances are detected in a footprint test

nervous system

nervous system phenotype ( J:215344 )

N • cerebellar histology is grossly normal, with no significant alterations in Purkinje cell morphology in terms of alignment, density, axonal elongation or dendritic structure

impaired synaptic plasticity ( J:215344 )

• mice show impaired cerebellar long-term synaptic plasticity (LTD and LTP) at the parallel fiber (PF)-Purkinje cell synapse

reduced long-term potentiation ( J:215344 )

• although Purkinje cells exhibit long-lasting potentiated PF-evoked excitatory post synaptic currents (EPSCs) after 300 PF-stimuli at 1 Hz, the amplitude of LTP is significantly smaller than that in control mice

absent long-term depression ( J:215344 )

• Purkinje cells fail to exhibit depressed PF-evoked EPSCs after conjunctive stimuli, unlike in control mice