Phenotypes Associated with This Genotype

Genotype
MGI:5825059

• Allelic Composition: Tg(BAC144D14)5D3Masu/0
• Genetic Background: B6J.Cg-Tg(BAC144D14)5D3Masu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased brown adipose tissue amount ( J:232408 )

• P7 interscapular brown fat depots are heavier as a proportion of body weight by 30%

increased brown fat cell number ( J:232408 )

• interscapular brown adipose tissue depots show increased cellularity

abnormal beige fat cell morphology ( J:232408 )

• two markers of brown adipose tissue (UCP1 and Elovl3) are elevated in retroperitoneal white adipose tissue, indicating an increase in BEIGE cells or browing of white adipose tissue

• P7 retroperitoneal white adipose tissue depots show clusters of cells that possess BEIGE characteristics, including a larger volume of cytoplasm, numerous mitochondria, smaller, multilocular, lipid droplets, and increased markers of brown adipose tissue not seen in wild-type white adipose tissue

decreased inguinal fat pad weight ( J:232408 )

decreased mesenteric fat pad weight ( J:232408 )

abnormal retroperitoneal fat pad morphology ( J:232408 )

• retroperitoneal white adipose tissue shows an abundance of smaller adipocytes with a multilocular appearance

decreased retroperitoneal fat pad weight ( J:232408 )

abnormal interscapular fat pad morphology ( J:232408 )

• P7 interscapular brown fat depots show increased cellularity and mitochondrial DNA content

increased interscapular fat pad weight ( J:232408 )

• P7 interscapular brown fat depots are heavier as a proportion of body weight by 30%

abnormal white adipose tissue morphology ( J:232408 )

• reduction in weight of mesenteric, inguinal, and retroperitoneal white adipose tissue depots relative to total body weight

growth/size/body

decreased birth weight ( J:232408 )

• newborns are lighter

decreased body weight ( J:232408 )

• males and females are lighter at 10 weeks of age

decreased fetal weight ( J:232408 )

• fetuses are lighter at E18.5

homeostasis/metabolism

hypoglycemia ( J:232408 )

• hypoglycemia in the fed state

increased body temperature ( J:232408 )

• basal body temperature is elevated

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Silver-Russell syndrome		DOID:14681	OMIM:180860	J:232408