Phenotypes Associated with This Genotype

Genotype
MGI:5825356

• Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased B cell acute lymphoblastic leukemia incidence ( J:226241 )

• mice develop acute leukemia with an incidence of 7% at 12 months of age

• leukemia cells are present in the bone marrow, spleen, lymph nodes and infiltrate multiple organs, including the CNS

• 94% of leukemias have a B cell precursor phenotype

hematopoietic system

enlarged spleen ( J:226241 )

• in leukemic mice

abnormal pro-B cell morphology ( J:226241 )

• progenitor B cells proliferate extensively in methylcellulose culture supplemented with IL-7, SCF, and FLT3 and are severely compromised in the their ability to differentiate into CD43- cells compared with progenitor B cells from controls indicating enhanced proliferation of progenitor B cells

abnormal pro-B cell differentiation ( J:226241 )

• mice show perturbed early B cell progenitor cell differentiation

arrested B cell differentiation ( J:226241 )

• leukemic blasts are arrested at the pro/pre-B stage of B cell precursor differentiation

anemia ( J:226241 )

• in leukemic mice

thrombocytopenia ( J:226241 )

• in leukemic mice

decreased B cell number ( J:226241 )

• a lower percentage of B cells are seen in the peripheral blood over a 30 week period in healthy preleukemic mice

decreased immature B cell number ( J:226241 )

• decrease in immature and recirculating B cells in the bone marrow in healthy preleukemic mice

increased leukocyte cell number ( J:226241 )

• leukemic mice present with leukocytosis

abnormal B cell physiology ( J:226241 )

• enhanced proliferation of progenitor B cells

• preleukemic mice irradiated sublethally to deplete the endogenous B cell populations show regeneration of B cell progenitors with a dramatic expansion of B220^lo progenitor cell population indicating enhanced B cell progenitor self-renewal

immune system

enlarged spleen ( J:226241 )

• in leukemic mice

abnormal pro-B cell morphology ( J:226241 )

• progenitor B cells proliferate extensively in methylcellulose culture supplemented with IL-7, SCF, and FLT3 and are severely compromised in the their ability to differentiate into CD43- cells compared with progenitor B cells from controls indicating enhanced proliferation of progenitor B cells

abnormal pro-B cell differentiation ( J:226241 )

• mice show perturbed early B cell progenitor cell differentiation

arrested B cell differentiation ( J:226241 )

• leukemic blasts are arrested at the pro/pre-B stage of B cell precursor differentiation

decreased B cell number ( J:226241 )

• a lower percentage of B cells are seen in the peripheral blood over a 30 week period in healthy preleukemic mice

decreased immature B cell number ( J:226241 )

• decrease in immature and recirculating B cells in the bone marrow in healthy preleukemic mice

increased leukocyte cell number ( J:226241 )

• leukemic mice present with leukocytosis

abnormal B cell physiology ( J:226241 )

• enhanced proliferation of progenitor B cells

• preleukemic mice irradiated sublethally to deplete the endogenous B cell populations show regeneration of B cell progenitors with a dramatic expansion of B220^lo progenitor cell population indicating enhanced B cell progenitor self-renewal

enlarged lymph nodes ( J:226241 )

• in leukemic mice

liver/biliary system

enlarged liver ( J:226241 )

• in leukemic mice

growth/size/body

enlarged liver ( J:226241 )

• in leukemic mice

enlarged spleen ( J:226241 )

• in leukemic mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:226241