Phenotypes Associated with This Genotype

Genotype
MGI:5827756

• Allelic Composition: Tg(MMTV-rtTA)1Lach/0; Tg(tetO-Kras2)12Hev/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:133578 )

♀ • mice fed doxycycline after weaning develop mammary gland hyperplasia, progress to hyperplastic alveolar nodules, and then palpable oligofocal mammary tumors with a median latency of 22 weeks

integument

increased mammary gland tumor incidence ( J:133578 )

♀ • mice fed doxycycline after weaning develop mammary gland hyperplasia, progress to hyperplastic alveolar nodules, and then palpable oligofocal mammary tumors with a median latency of 22 weeks

mammary gland hyperplasia ( J:133578 )

♀ • mice fed doxycycline after weaning develop mammary gland hyperplasia as early as one week after induction

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:133578 )

♀ • mice fed doxycycline after weaning develop mammary gland hyperplasia, progress to hyperplastic alveolar nodules, and then palpable oligofocal mammary tumors with a median latency of 22 weeks

mammary gland hyperplasia ( J:133578 )

♀ • mice fed doxycycline after weaning develop mammary gland hyperplasia as early as one week after induction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:133578