Analysis Tools
neoplasm
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• diffuse mammary hyperplasia is seen at 7 days after doxycycline administration, numerous tumor nodules are seen throughout the glandular tree at 14 days and confluent tumors are present at 21 days
• removal of doxycycline results in apoptosis and reduced proliferation of tumors
• after doxycycline withdrawal, almost all of the transformed mammary glands completely regress to a nonpalpable state within 2 weeks
• solitary mammary tumors develop after withdrawal of doxycycline in 20 of 36 mice at a median age of 53 weeks, indicating recurrent tumors
• in the absence of doxycycline, only one of 31 mice develop a mammary tumor
• tumor recurrence is associated with reactivation of oncogenic transgenes and somatic mutations in the rtTA transgene
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integument
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• diffuse mammary hyperplasia is seen at 7 days after doxycycline administration, numerous tumor nodules are seen throughout the glandular tree at 14 days and confluent tumors are present at 21 days
• removal of doxycycline results in apoptosis and reduced proliferation of tumors
• after doxycycline withdrawal, almost all of the transformed mammary glands completely regress to a nonpalpable state within 2 weeks
• solitary mammary tumors develop after withdrawal of doxycycline in 20 of 36 mice at a median age of 53 weeks, indicating recurrent tumors
• in the absence of doxycycline, only one of 31 mice develop a mammary tumor
• tumor recurrence is associated with reactivation of oncogenic transgenes and somatic mutations in the rtTA transgene
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• diffuse mammary hyperplasia is seen at 7 days after doxycycline administration
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endocrine/exocrine glands
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• diffuse mammary hyperplasia is seen at 7 days after doxycycline administration, numerous tumor nodules are seen throughout the glandular tree at 14 days and confluent tumors are present at 21 days
• removal of doxycycline results in apoptosis and reduced proliferation of tumors
• after doxycycline withdrawal, almost all of the transformed mammary glands completely regress to a nonpalpable state within 2 weeks
• solitary mammary tumors develop after withdrawal of doxycycline in 20 of 36 mice at a median age of 53 weeks, indicating recurrent tumors
• in the absence of doxycycline, only one of 31 mice develop a mammary tumor
• tumor recurrence is associated with reactivation of oncogenic transgenes and somatic mutations in the rtTA transgene
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• diffuse mammary hyperplasia is seen at 7 days after doxycycline administration
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:114480 | |
