Analysis Tools
endocrine/exocrine glands
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• increase in number CD45+ leukocytes in prostate tissue as compared to control (lacking JAG1 over expression)
• prostate tissue in 15/16 mutant mice contains large papillary structures with complex glandular architecture
• blood vessel density in prostate is 1.8 fold more than in control
• increased collagen deposition at the prostatic peri-glandular spaces
• presence of reactive stroma
• stromal cell layer is disrupted and thinner with increased vimentin staining in peri-glandular stromal cells
• prostate tissues contain more inflammatory foci as compared to controls (lacking JAG1 overexpression)
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• 62.5% mutant mice (as compared to 20% in controls lacking JAG1 overexpression) have a mass of poorly differentiated adenocarcinoma extended into lumen of seminal vesicles and replacing the normal lining of epithelium
• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
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• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
• mice develop a higher grade reactive stroma with lymphocytic infiltration as compared to control (lacking JAG1 overexpression)
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neoplasm
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• 62.5% mutant mice (as compared to 20% in controls lacking JAG1 overexpression) have a mass of poorly differentiated adenocarcinoma extended into lumen of seminal vesicles and replacing the normal lining of epithelium
• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
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• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
• mice develop a higher grade reactive stroma with lymphocytic infiltration as compared to control (lacking JAG1 overexpression)
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reproductive system
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• increase in number CD45+ leukocytes in prostate tissue as compared to control (lacking JAG1 over expression)
• prostate tissue in 15/16 mutant mice contains large papillary structures with complex glandular architecture
• blood vessel density in prostate is 1.8 fold more than in control
• increased collagen deposition at the prostatic peri-glandular spaces
• presence of reactive stroma
• stromal cell layer is disrupted and thinner with increased vimentin staining in peri-glandular stromal cells
• prostate tissues contain more inflammatory foci as compared to controls (lacking JAG1 overexpression)
|
|
• 62.5% mutant mice (as compared to 20% in controls lacking JAG1 overexpression) have a mass of poorly differentiated adenocarcinoma extended into lumen of seminal vesicles and replacing the normal lining of epithelium
• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
|
|
• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
• mice develop a higher grade reactive stroma with lymphocytic infiltration as compared to control (lacking JAG1 overexpression)
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| prostate cancer | DOID:10283 |
OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 |
J:238768 | |
