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Phenotypes Associated with This Genotype
Genotype
MGI:5827768
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)20Fwan/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Pbsn-cre)20Fwan mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
• prostate tissue in 2/8 mutant mice contains large papillary structures with complex glandular architecture
• mice develop a lower grade reactive stroma with lymphocytic infiltration as compared to mice with JAG1 overexpression

neoplasm
• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
• prostate tissue in 2/8 mutant mice contains large papillary structures with complex glandular architecture
• mice develop a lower grade reactive stroma with lymphocytic infiltration as compared to mice with JAG1 overexpression

reproductive system
• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year
• prostate tissue in 2/8 mutant mice contains large papillary structures with complex glandular architecture
• mice develop a lower grade reactive stroma with lymphocytic infiltration as compared to mice with JAG1 overexpression


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory