Phenotypes Associated with This Genotype

Genotype
MGI:5828153

• Allelic Composition: Tg(Fabp4-ENPP1)#Naba/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased fat cell size ( J:182179 )

• mice fed a high-fat diet exhibit a lower adipocyte size than wild-type mice

behavior/neurological

decreased food intake ( J:182179 )

• mice fed a high-fat diet show lower food intake than wild-type mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:182179 )

• mice fed a high-fat diet exhibit a lower body weight than wild-type mice

• however, mice fed a regular chow exhibit similar body weight as wild-type mice at week 24

• however, after a high-fat diet with pair-feeding protocol, mice show similar weight as wild-type mice

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:182179 )

• mice fed a high-fat diet exhibit a lower body weight than wild-type mice

• however, mice fed a regular chow exhibit similar body weight as wild-type mice at week 24

• however, after a high-fat diet with pair-feeding protocol, mice show similar weight as wild-type mice

increased circulating insulin level ( J:182179 )

• mice pair-fed with a high-fat diet exhibit higher insulin concentration during intraperitoneal glucose tolerance test

• however, mice fed regular chow exhibit normal plasma insulin concentrations

decreased circulating leptin level ( J:182179 )

• mice exhibit decreased plasma concentrations of leptin

increased circulating free fatty acids level ( J:182179 )

• mice fed a high-fat diet show higher plasma free fatty acids after 5 hours of fasting followed by insulin administration, indicating incomplete suppression of plasma fatty acid levels during hyperinsulinemia

• mice exhibit increased plasma concentrations of free fatty acids after being exposed to 12 weeks of a high fat diet with pair-feeding protocol

increased circulating triglyceride level ( J:182179 )

• mice exhibit increased plasma concentrations of triglycerides

impaired glucose tolerance ( J:182179 )

• mice pair-fed with a high-fat diet exhibit higher plasma glucose during intraperitoneal glucose tolerance test

• however, mice fed regular chow exhibit normal plasma glucose concentrations

insulin resistance ( J:182179 )

• glucose suppression following insulin administration is decreased in mice on a high-fat diet

increased liver triglyceride level ( J:182179 )

• increase in triglyceride levels in the liver of mice pair-fed with a high-fat diet for 12 weeks

liver/biliary system

increased liver triglyceride level ( J:182179 )

• increase in triglyceride levels in the liver of mice pair-fed with a high-fat diet for 12 weeks

hepatic steatosis ( J:182179 )

• mice pair-fed with a high-fat diet develop fatty liver

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
abdominal obesity-metabolic syndrome 1		DOID:14221	OMIM:605552	J:182179