Phenotypes Associated with This Genotype

Genotype
MGI:5828524

• Allelic Composition: Lepr^db/Lepr^db; Tg(SHBG)4-aGlha/0
• Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:232827 )

• progressive increase in body weight from 6 to 12 weeks of age, however a 15-20% reduction in body weight is seen compared to single Lepr^db homozygotes

increased kidney weight ( J:232827 )

increased liver weight ( J:232827 )

• increase in liver weight in both males and females compared to either single heterozygous mice, however liver weight in males is reduced compared to single Lepr^db homozygotes

adipose tissue

abnormal adipose tissue morphology ( J:232827 )

• increase in adipose tissue weight compared to either single heterozygous mice, however visceral adipose tissue weight is reduced compared to single Lepr^db homozygotes

homeostasis/metabolism

abnormal blood homeostasis ( J:232827 )

♂ • plasma levels of SHBG in obese males do not increase from week 4 to week 6 and remain lower at 8 weeks of age unlike in controls and this is due to altered hepatic HNF-4alpha and PPAR-gamma mRNA and protein levels

hyperglycemia ( J:232827 )

• obese mice develop hyperglycemia after 6 weeks of age to a similar extent as single Lepr^db homozygotes

increased circulating testosterone level ( J:232827 )

♂ • total testosterone plasma levels are reduced in obese males

increased circulating insulin level ( J:232827 )

• higher plasma insulin levels in obese males and females comparable to single Lepr^db homozygotes

increased circulating leptin level ( J:232827 )

• higher plasma leptin levels in obese males and females comparable to single Lepr^db homozygotes

increased circulating cholesterol level ( J:232827 )

• obese males and females exhibit higher plasma cholesterol levels comparable to single Lepr^db homozygotes

increased circulating free fatty acids level ( J:232827 )

• higher plasma nonsterified fatty acids level in obese males and females comparable to single Lepr^db homozygotes

increased circulating triglyceride level ( J:232827 )

• obese males and females exhibit higher plasma triglycerides with levels comparable to single Lepr^db homozygotes

increased liver triglyceride level ( J:232827 )

liver/biliary system

increased liver weight ( J:232827 )

• increase in liver weight in both males and females compared to either single heterozygous mice, however liver weight in males is reduced compared to single Lepr^db homozygotes

increased liver triglyceride level ( J:232827 )

hepatic steatosis ( J:232827 )

• mice develop fatty liver

renal/urinary system

increased kidney weight ( J:232827 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:232827