Phenotypes Associated with This Genotype

Genotype
MGI:5828598

• Allelic Composition: Tg(CAG-cat,-Ptpn11*Q510E)#Krnz/0; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:237450 )

• all embryos die by E14.5

cardiovascular system

abnormal atrioventricular cushion morphology ( J:237450 )

• endocardial cushion volumes are increased by 81% in E13.5 embryos

abnormal atrioventricular valve morphology ( J:237450 )

• septal leaflets of the atrioventricular valves are thicker in E13.5 embryos

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Noonan syndrome with multiple lentigines		DOID:14291	OMIM:PS151100	J:237450