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Phenotypes Associated with This Genotype
Genotype
MGI:5882127
Allelic
Composition
Tg(CMV-Tsc2*)1Arbi/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-Tsc2*)1Arbi mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit a mild, but significantly reduced latency to fall in consecutive trials on day two on the rotarod compared to wild-type mice, indicating a modest impairment in motor learning skills
• however, mice do not exhibit enhanced repetitive behaviors, show normal reversal learning tasks in water-based Y maze, normal associative fear learning and normal long-lasting contextual fear memory, and normal sensorimotor gating
• mice exhibit normal spatial learning in the Morris water maze but a mild impairment on the last day of acquisition and mice have a preference for the target quadrant, indicating normal spatial memory
• in a reciprocal social interaction task, mice spend less time interacting with a conspecific mouse compared to wild-type mice
• in the social preference task, mice have normal preference toward interacting with a novel social target than with a familiar one, however they exhibit a social impairment when challenged 24 hours later in a social novelty test, with mice spending a similar amount of time interacting with both novel and familiar social targets unlike wild-type mice that interact more with the novel social target
• however, mice show habituation to the familiar social target, showing a decrease in interaction with this target 24 hours after initial interaction and normal behavior in the novel object recognition task

integument
• mice develop a fibrovascular collagenoma in the dermis that resembles Shagreen patch in patients with tuberous sclerosis
• fibrovascular proliferation at the junction between the dermis and muscle and this collagenous proliferation is rich in mast cells

neoplasm
• mice show numerous small subpial aggregates of external granule cells in the cerebellum that fail to migrate to the appropriate site resembling brain hamartoma
• fibrovascular proliferation at the junction between the dermis and muscle and this collagenous proliferation is rich in mast cells

nervous system
• mice show aggregates of granular cells at the surface of the cerebellum immediately underneath the pia
• aggregates range in size from 10-25 cells and form linear arrangements along the surface of the molecular layer or as small nodules that extend into the subarachnoid space
• mice show impaired hippocampal metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD)
• mice treated with the MEK inhibitor U0126 show rescue of mGluR-dependent LTD
• however, basal synaptic transmission in hippocampal area CA1, paired-pulse facilitation in the hippocampus using both short and long interpulse intervals, early phase long-term potentiation and late phase long-term potentiation in the hippocampus, and fiber volley amplitude measured with increasing stimulation are unaltered

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
tuberous sclerosis DOID:13515 OMIM:PS191100
J:96943 , J:179850


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory