Phenotypes Associated with This Genotype

Genotype
MGI:5882410

• Allelic Composition: Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs; Tg(CKMM-tTA)A3Rhvh/0; Tg(tetO-Hgf,-EGFP)24Tcre/0
• Genetic Background: involves: 129X1/SvJ * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

skeletal muscle hyperplasia ( J:237183 )

• 32% of mice that develop embryonal rhabdomyosarcoma exhibit muscle hyperplasia while 68% of mice develop embryonal rhabdomyosarcoma without muscle hyperplasia

increased rhabdomyosarcoma incidence ( J:237183 )

• all mice develop tumors, mainly multi-step embryonal rhabdomyosarcoma with a short latency of 3.95 months

• embryonal rhabdomyosarcoma originates from satellite cells

• treatment of mice with doxycycline when tumors become palpable does not impair tumor growth

• mice maintained under doxycycline treatment until P10 develop tumors after doxycycline removal

neoplasm

increased rhabdomyosarcoma incidence ( J:237183 )

• all mice develop tumors, mainly multi-step embryonal rhabdomyosarcoma with a short latency of 3.95 months

• embryonal rhabdomyosarcoma originates from satellite cells

• treatment of mice with doxycycline when tumors become palpable does not impair tumor growth

• mice maintained under doxycycline treatment until P10 develop tumors after doxycycline removal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
embryonal rhabdomyosarcoma		DOID:3246	OMIM:268210	J:237183