Phenotypes Associated with This Genotype

Genotype
MGI:5882988

cn33

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Notch1)Dam}/Gt(ROSA)26Sor⁺; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:233131 )

• smaller body weight at P24

postnatal growth retardation ( J:233131 )

• from 2 weeks of age, mice show progressive growth retardation

skeleton

abnormal skeleton morphology ( J:233131 )

• thickened bones at 4 weeks of age

• cortices of bones are composed on woven bone in 2 month old mice

thick neurocranium ( J:233131 )

• increase in thickness of calvarial bone

abnormal bone marrow cavity morphology ( J:233131 )

• marrow space is enclosed by fibrotic cells with features of early osteoblastic precursors

abnormal trabecular bone morphology ( J:233131 )

• trabecular bone is composed predominately of immature woven rather than lamellar bone

• trabecular bone architecture is altered in 2 month old mice

increased trabecular bone volume ( J:233131 )

• trabecular bone volume/tissue volume is increased by more than 6-fold in 2 month old mice

increased bone trabecula number ( J:233131 )

• increase in trabecular number in 2 month old mice

decreased bone trabecular spacing ( J:233131 )

• decrease in trabecular spaces in 2 month old mice

increased trabecular bone thickness ( J:233131 )

• increase in trabecular bone thickness in 2 month old mice

increased bone mass ( J:233131 )

• increase in bone mass due to increased bone formation

osteosclerosis ( J:233131 )

• generalized osteosclerotic phenotype in skulls, rib cages, tail vertebrae, and limb long bones

limbs/digits/tail

kinked tail ( J:233131 )

• from 2 weeks of age, mice show a kinky tail

craniofacial

thick neurocranium ( J:233131 )

• increase in thickness of calvarial bone