mortality/aging
• mice die on average at 20.9 weeks of age, with survival ranging between 12 and 35 weeks
|
cardiovascular system
• myocyte enlargement without disarray
|
• prominent left atria
|
• biventricular cardiac dilation begins at 4 months of age
|
• massive left ventricular dilation
|
• extensive interstitial fibrosis
|
• dilated cardiomyopathy rapidly progresses
|
• mice develop diminished left ventricle contractility as heart chamber size increases
|
• the decay in calcium transients is prolonged in myocytes
• myocyte relaxation is delayed
• however, SR calcium-release velocities, time to 90% peak calcium signal and cell shortening velocities are similar to wild-type
• beta-adrenergic stimulation does not normalize the depressed calcium kinetics
|
• mice show symptoms of terminal heart failure including dyspnea, lethargy, and peripheral cyanosis
|
behavior/neurological
homeostasis/metabolism
• mice eventually show symptoms of terminal heart failure including terminal cyanosis
|
liver/biliary system
muscle
• myocyte enlargement without disarray
|
• dilated cardiomyopathy rapidly progresses
|
• mice develop diminished left ventricle contractility as heart chamber size increases
|
respiratory system
• mice eventually show symptoms of terminal heart failure including dyspnea
|
growth/size/body
cellular
• extensive interstitial fibrosis
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
dilated cardiomyopathy 1P | DOID:0110439 |
OMIM:609909 |
J:82353 |