behavior/neurological
• 2 of 20 mice at weaning age show abnormal Preyer reflex, with a further 10 becoming progressively unresponsive between 8 and 12 weeks of age, and all mice becoming unresponsive by 16 weeks
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• when mice are placed on their backs, they stay supine without trying to rotate to an upright position
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• after 2 weeks of age, more than 90% of mice have a one side tilted head and show impaired balance
• when held by the tail and dropped onto a soft surface, mutants fall on their back or their sides instead of landing on their feet like wild-type mice, indicating a saccular defect
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• mutants are unable to swim or float properly, but remain submerged, completely disoriented, while turning under water
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• after 2 weeks of age, more than 90% of mice have a one side tilted head and show impaired balance
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• 10% of mice show a circulating behavior after P10 that persists into adulthood
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nervous system
• stereocilia of the sensory hair cells are less numerous
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hearing/vestibular/ear
• stereocilia of the sensory hair cells are less numerous
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• older (> P100) mice exhibit detached cupula in the crista ampullaris
• however, otoconia are preserved and the cochlea is normal
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• anomalies in the saccular macula
• only a few remnants of the otoconial membrane are present on saccular maculae
• however, the supporting cells at the base of the maculae are preserved
• numerous type I hair cells of the maculae have a shrunken nucleus
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
autosomal recessive nonsyndromic deafness 18B | DOID:0110474 |
OMIM:614945 |
J:234038 |