Phenotypes Associated with This Genotype

Genotype
MGI:5883306

• Allelic Composition: Il2ra^tm1Dw/Il2ra^tm1Dw
• Genetic Background: B6.129S4-Il2ra^tm1Dw/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal salivary gland morphology ( J:125129 )

• severe acinar gland destruction

abnormal salivary gland duct morphology ( J:125129 )

• mild ductal changes in the salivary gland

large intestinal inflammation ( J:125129 )

• severe inflammation in the colon

decreased salivation ( J:125129 )

• mice exhibit an increase in the lag time and a reduction of saliva production when treated with Pilocarpine, indicating loss of salivary gland function

salivary gland inflammation ( J:125129 )

• severe inflammation in the salivary glands

• major population of infiltrating leukocytes are lymphocytes and to a much lower extent neutrophils

• salivary glands show presence of a large fraction of T cells and a ratio of CD4+/CD8+ of 1/2

• although more Gr-1+ cells are seen in the salivary glands, the absolute number of neutrophils is relatively small

endocrine/exocrine glands

abnormal salivary gland morphology ( J:125129 )

• severe acinar gland destruction

abnormal salivary gland duct morphology ( J:125129 )

• mild ductal changes in the salivary gland

decreased salivation ( J:125129 )

• mice exhibit an increase in the lag time and a reduction of saliva production when treated with Pilocarpine, indicating loss of salivary gland function

salivary gland inflammation ( J:125129 )

• severe inflammation in the salivary glands

• major population of infiltrating leukocytes are lymphocytes and to a much lower extent neutrophils

• salivary glands show presence of a large fraction of T cells and a ratio of CD4+/CD8+ of 1/2

• although more Gr-1+ cells are seen in the salivary glands, the absolute number of neutrophils is relatively small

lacrimal gland inflammation ( J:125129 )

• severe inflammation in the lacrimal glands

homeostasis/metabolism

decreased salivation ( J:125129 )

• mice exhibit an increase in the lag time and a reduction of saliva production when treated with Pilocarpine, indicating loss of salivary gland function

immune system

large intestinal inflammation ( J:125129 )

• severe inflammation in the colon

salivary gland inflammation ( J:125129 )

• severe inflammation in the salivary glands

• major population of infiltrating leukocytes are lymphocytes and to a much lower extent neutrophils

• salivary glands show presence of a large fraction of T cells and a ratio of CD4+/CD8+ of 1/2

• although more Gr-1+ cells are seen in the salivary glands, the absolute number of neutrophils is relatively small

lacrimal gland inflammation ( J:125129 )

• severe inflammation in the lacrimal glands

lung inflammation ( J:125129 )

• severe lung inflammation

• however, mice do not exhibit skin inflammation

respiratory system

lung inflammation ( J:125129 )

• severe lung inflammation

• however, mice do not exhibit skin inflammation

vision/eye

lacrimal gland inflammation ( J:125129 )

• severe inflammation in the lacrimal glands

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:125129