Phenotypes Associated with This Genotype

Genotype
MGI:5883309

ot7

• Allelic Composition: Foxp3^sf/Y
• Genetic Background: B6.Cg-Foxp3^sf/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

salivary gland inflammation ( J:125129 )

• transfer of mutant lymph node cells to RAG-1 knock-out mice induces severe inflammation in the salivary glands and loss of salivary function

• feeding mutants with a TLR agonist, LPS, induces inflammation in the salivary glands

endocrine/exocrine glands

salivary gland inflammation ( J:125129 )

• transfer of mutant lymph node cells to RAG-1 knock-out mice induces severe inflammation in the salivary glands and loss of salivary function

• feeding mutants with a TLR agonist, LPS, induces inflammation in the salivary glands

immune system

salivary gland inflammation ( J:125129 )

• transfer of mutant lymph node cells to RAG-1 knock-out mice induces severe inflammation in the salivary glands and loss of salivary function

• feeding mutants with a TLR agonist, LPS, induces inflammation in the salivary glands

lung inflammation ( J:125129 )

• severe lung inflammation

• however, salivary gland or lacrimal gland inflammation is not seen

skin inflammation ( J:125129 )

integument

skin inflammation ( J:125129 )

respiratory system

lung inflammation ( J:125129 )

• severe lung inflammation

• however, salivary gland or lacrimal gland inflammation is not seen