Phenotypes Associated with This Genotype

Genotype
MGI:5883506

• Allelic
  Composition
• Genetic Background: YBR/EiJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal iris stromal pigmentation ( J:234169 )

immune system

decreased susceptibility to Retroviridae infection ( J:263130 )

• although these inbred mice can be infected with MMTV and transmit the virus, virus productionn is attenuated relative to that in other inbreds and over successive generations the infection is cleared through a mechanism requiring T cells

nervous system

retina ganglion cell degeneration ( J:234169 )

• in older animals there is loss of retinal ganglion cells and thinning of the nerve fiber layer that contains their axons, but no other retinal layer abnormality is found

abnormal optic nerve morphology ( J:234169 )

• older mice show optic nerve excavation and remodeling, consistent with glaucomatous neurodegeneration

optic nerve degeneration ( J:234169 )

• by 14 months of age approximately 60% of YBR/EiJ eyes show severe axon loss with extensive gliosis and optic nerve damage

cardiovascular system

cornea vascularization ( J:234169 )

• some YBR/EiJ mice develop vascularization of the cornea at 1 year of age

hearing/vestibular/ear

abnormal hearing electrophysiology ( J:123543 )

• abnormal tympanogram relative to CBA/CaJ and a panel of 61 inbred strains

increased or absent threshold for auditory brainstem response ( J:123543 )

vision/eye

cornea vascularization ( J:234169 )

• some YBR/EiJ mice develop vascularization of the cornea at 1 year of age

retina ganglion cell degeneration ( J:234169 )

• in older animals there is loss of retinal ganglion cells and thinning of the nerve fiber layer that contains their axons, but no other retinal layer abnormality is found

abnormal optic nerve morphology ( J:234169 )

• older mice show optic nerve excavation and remodeling, consistent with glaucomatous neurodegeneration

optic nerve degeneration ( J:234169 )

• by 14 months of age approximately 60% of YBR/EiJ eyes show severe axon loss with extensive gliosis and optic nerve damage

abnormal iris stroma morphology ( J:234169 )

• YBR/EiJ develop age-related iris stromal atrophy with increasing iris depigmentation and iris stromal cell loss but no iris pigment epithelial cell loss

abnormal iris stromal pigmentation ( J:234169 )

iris stroma hypoplasia ( J:234169 )

• by 9 months of age itis stromal atrophy causes thinning of the iris stroma and peripupillary atrophy with increasing transillumination defects

abnormal aqueous humor ( J:234169 )

• as these mice age the deteriorating iris stroma causes released pigment and debris to accumulate at the iridocorneal angle, focal tissue adhesions form, angle closure occurs and there is a block of aqueous humor drainage

ocular hypertension ( J:234169 )

• beginning at approximately 6 to 7 months of age and increasing with age, apparently as a result of pigment debris released from deteriorating iris stroma accumulating at the iridocorneal angle