Phenotypes Associated with This Genotype

Genotype
MGI:5897776

• Allelic Composition: Prkar1a^tm1.2Lsk/Prkar1a^tm1.2Lsk; Tg(TPO-cre)1Shk/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:241066 )

• thyroids show increased cellularity but retain a follicular pattern of growth

enlarged thyroid gland ( J:241066 )

• 100% of mice exhibit enlargement of the thyroid

increased thyroid carcinoma incidence ( J:225245 , J:241066 )

• thyroids exhibit locally invasive follicular thyroid carcinoma (J:225245)

• tumors exhibit high proliferation rate (J:225245)

• mice develop follicular thyroid carcinoma at a rate of 43% by one year of age (J:241066)

• tumors exhibit increased proliferation compared to wild-type thyroid glands (J:241066)

• however, none of the tumors show widely invasive or angio-invasive behavior (J:241066)

increased activity of thyroid gland ( J:241066 )

• mice are hyperthyroid

homeostasis/metabolism

increased thyroxine level ( J:241066 )

• T4 levels are elevated, indicating hyperthyroidism

decreased thyroid-stimulating hormone level ( J:241066 )

• TSH levels are lower but not statistically significant due to wide variation in wild-type mice

neoplasm

increased thyroid carcinoma incidence ( J:225245 , J:241066 )

• thyroids exhibit locally invasive follicular thyroid carcinoma (J:225245)

• tumors exhibit high proliferation rate (J:225245)

• mice develop follicular thyroid carcinoma at a rate of 43% by one year of age (J:241066)

• tumors exhibit increased proliferation compared to wild-type thyroid glands (J:241066)

• however, none of the tumors show widely invasive or angio-invasive behavior (J:241066)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
follicular thyroid carcinoma		DOID:3962	OMIM:188470	J:241066