mortality/aging
• median survival is 38.4 weeks
|
neoplasm
• 4-8 week old mice only show areas of well differentiated follicular carcinomas but go on to develop well-differentiated follicular carcinomas by 8-10 months of age exhibiting spindle cell morphology, giant, osteoclast-like, multinucleated cells and areas of osseous metaplasia resembling human thyroid anaplastic carcinomas
• anaplastic thyroid carcinomas undergo dedifferentiation, genomic instability and epithelial-to-mesenchymal transition and exhibit a shift from an oxidative to a glycolytic pathway
|
• aggressive tumors invade locally into the muscle and trachea and metastasize to the lungs in 28% of mice, or less often, to the liver
|
endocrine/exocrine glands
• all 8-10 month old mice exhibit enlarged thyroid gland causing severe tracheal compression
|
• 4-8 week old mice only show areas of well differentiated follicular carcinomas but go on to develop well-differentiated follicular carcinomas by 8-10 months of age exhibiting spindle cell morphology, giant, osteoclast-like, multinucleated cells and areas of osseous metaplasia resembling human thyroid anaplastic carcinomas
• anaplastic thyroid carcinomas undergo dedifferentiation, genomic instability and epithelial-to-mesenchymal transition and exhibit a shift from an oxidative to a glycolytic pathway
|
homeostasis/metabolism
• reduction in TSH serum levels
• however, T4 levels are normal
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
thyroid gland carcinoma | DOID:3963 | J:211100 |