Analysis Tools
muscle
reproductive system
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• no individuals are detected with more than 80% of mitochondria harboring the mutation without an increase in embryo death
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growth/size/body
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• in male, but not female, mice
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• in female and male mice, especially at high mutation levels
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• in male, but not female, mice
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• in male, but not female, mice
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cellular
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• cells exhibit a selection against high mutation levels in proliferating tissues
• impaired mitochondrial translation
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• defective in cells from a variety of tissues
• defective at 20 weeks in epithelial cells of colonic crypts
• defective at 40 weeks or older in smooth muscle surrounding the colon with greater than 60% of the nutation and occasionally in cardiomyocytes
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• impaired mitochondrial translation
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cardiovascular system
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• in female and male mice, especially at high mutation levels
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adipose tissue
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• in male, but not female, mice
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homeostasis/metabolism
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• impaired mitochondrial translation
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| mitochondrial metabolism disease | DOID:700 | J:238994 | ||
