Phenotypes Associated with This Genotype

Genotype
MGI:5902497

• Allelic Composition: B3gnt6^tm1Lx/B3gnt6^tm1Lx; C1galt1^tm1.1Rpmc/C1galt1^tm1.1Rpmc; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased duodenum glandular epithelium tumor incidence ( J:239765 )

• mice injected with tamoxifen at 1.5- to 4-months of age develop spontaneous duodenal tumors between 12 and 24 months of age, exhibiting mostly proliferative epithelium

increased duodenum adenocarcinoma incidence ( J:239765 )

• tumors in tamoxifen-injected mice are aggressive and advance to adenocarcinoma

neoplasm

increased duodenum glandular epithelium tumor incidence ( J:239765 )

• mice injected with tamoxifen at 1.5- to 4-months of age develop spontaneous duodenal tumors between 12 and 24 months of age, exhibiting mostly proliferative epithelium

increased duodenum adenocarcinoma incidence ( J:239765 )

• tumors in tamoxifen-injected mice are aggressive and advance to adenocarcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
duodenum cancer		DOID:10021		J:23965