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Phenotypes Associated with This Genotype
Genotype
MGI:5903778
cx2
Allelic
Composition		 Igktm1Dhu/Igktm1Dhu
Tg(H2-Ea-HA)HACIIAjca/0
Tg(Tcra/Tcrb)1Vbo/0
Genetic
Background		 C.Cg-Igktm1Dhu Tg(H2-Ea-HA)HACIIAjca Tg(Tcra/Tcrb)1Vbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Dhu mutation (1 available); any Igk mutation (26 available)
Tg(H2-Ea-HA)HACIIAjca mutation (1 available)
Tg(Tcra/Tcrb)1Vbo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune arthritis ( J:209872 )
• mice develop arthritis more quickly but with disease penetrance and severity similar to double Tg(Tcra/Tcrb)1Vbo/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

skeleton
autoimmune arthritis ( J:209872 )
• mice develop arthritis more quickly but with disease penetrance and severity similar to double Tg(Tcra/Tcrb)1Vbo/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory