Phenotypes Associated with This Genotype

Genotype
MGI:5904161

cn1

• Allelic Composition: Tg(Stra8-icre)1Reb/0; Zscan21^tm1.1Jiwa/Zscan21^tm1.1Jiwa
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatid morphology ( J:237046 )

♂ • testes show no round spermatids

abnormal spermatocyte morphology ( J:237046 )

♂ • testes show few spermatocytes, without round spermatids

abnormal X-Y chromosome synapsis during male meiosis ( J:237046 )

♂ • unsynapsed or partially synapsed chromosomes are seen in spermatocytes indicating failure of chromosomal synapsis

arrest of male meiosis ( J:237046 )

♂ • spermatocytes do not progress to meiotic prophase I

decreased testis weight ( J:237046 )

♂ • testis weight of adult males is less than 40% of heterozygotes

male infertility ( J:237046 )

♂ • males are infertile, with 6-8 week old males failing to produce offspring after natural mating with wild-type females for more than 4 months

cellular

abnormal spermatid morphology ( J:237046 )

♂ • testes show no round spermatids

abnormal spermatocyte morphology ( J:237046 )

♂ • testes show few spermatocytes, without round spermatids

abnormal X-Y chromosome synapsis during male meiosis ( J:237046 )

♂ • unsynapsed or partially synapsed chromosomes are seen in spermatocytes indicating failure of chromosomal synapsis

arrest of male meiosis ( J:237046 )

♂ • spermatocytes do not progress to meiotic prophase I

abnormal double-strand DNA break repair ( J:237046 )

♂ • failure of double-strand DNA break repair in spermatocytes as indicated by reduced MLH1 foci and RAD51 foci

endocrine/exocrine glands

decreased testis weight ( J:237046 )

♂ • testis weight of adult males is less than 40% of heterozygotes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:237046 )

♂ • failure of double-strand DNA break repair in spermatocytes as indicated by reduced MLH1 foci and RAD51 foci