Phenotypes Associated with This Genotype

Genotype
MGI:5905888

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺; Tg(Myh6-2A)#Know/0
• Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:128060 )

♂ • cardiac cells from tamoxifen-treated mice show severe cytoskeletal changes such as myofibrillar collapse with a haphazard arrangement, a decrease in myofibril number, and an increase in swollen mitochondria

♂ • irregularity in the spacing between cells in the intercalated discs and irregularity of the sarcolemmal membrane in the hearts of tamoxifen-treated mice

abnormal intercalated disk morphology ( J:128060 )

♂ • myocardial fibers of tamoxifen-treated mice show abnormalities of intercalated discs

increased heart atrium size ( J:128060 )

♂ • biatrial enlargement in tamoxifen-treated mice

increased heart ventricle size ( J:128060 )

♂ • severe ventricular enlargement in tamoxifen-treated mice

cardiac interstitial fibrosis ( J:128060 )

♂ • small amount of interstitial fibrosis in tamoxifen-treated mice

dilated cardiomyopathy ( J:128060 )

♂ • heart weight-to-body weight ratio is increased 22 days after tamoxifen administration

decreased heart left ventricle muscle contractility ( J:128060 )

♂ • decrease in the fractional shortening of the left ventricle of tamoxifen-treated mice

abnormal heart echocardiography feature ( J:128060 )

♂ • increase in left ventricular end-diastolic dimension and end-systolic dimension in tamoxifen-treated mice

heart inflammation ( J:128060 )

♂ • tamoxifen-treated mice show only a small increase in inflammation

homeostasis/metabolism

ascites ( J:128060 )

♂ • in tamoxifen-treated mice

pleural effusion ( J:128060 )

♂ • in tamoxifen-treated mice

immune system

heart inflammation ( J:128060 )

♂ • tamoxifen-treated mice show only a small increase in inflammation

muscle

abnormal myocardial fiber morphology ( J:128060 )

♂ • cardiac cells from tamoxifen-treated mice show severe cytoskeletal changes such as myofibrillar collapse with a haphazard arrangement, a decrease in myofibril number, and an increase in swollen mitochondria

♂ • irregularity in the spacing between cells in the intercalated discs and irregularity of the sarcolemmal membrane in the hearts of tamoxifen-treated mice

abnormal intercalated disk morphology ( J:128060 )

♂ • myocardial fibers of tamoxifen-treated mice show abnormalities of intercalated discs

dilated cardiomyopathy ( J:128060 )

♂ • heart weight-to-body weight ratio is increased 22 days after tamoxifen administration

decreased heart left ventricle muscle contractility ( J:128060 )

♂ • decrease in the fractional shortening of the left ventricle of tamoxifen-treated mice

abnormal sarcolemma morphology ( J:128060 )

♂ • the sarcolemmal membrane is disrupted in myocardial fibers of tamoxifen-treated mice

abnormal sarcomere morphology ( J:128060 )

♂ • myocardial fibers from tamoxifen-treated mice show shortened sarcomeres

abnormal Z line morphology ( J:128060 )

♂ • myocardial fibers from tamoxifen-treated mice show fuzzy Z-lines

respiratory system

pleural effusion ( J:128060 )

♂ • in tamoxifen-treated mice

cellular

cardiac interstitial fibrosis ( J:128060 )

♂ • small amount of interstitial fibrosis in tamoxifen-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:128060