Phenotypes Associated with This Genotype

Genotype
MGI:5906253

• Allelic Composition: Tg(Myh6-Snai1)B10Jcc/Tg(Myh6-Snai1)B10Jcc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:126850 )

• all mice die by 2 months of age and 50% die within 36 days after birth

cardiovascular system

enlarged heart ( J:126850 )

• enlarged hearts with dilation of the ventricular chambers

thin ventricular wall ( J:126850 )

• dilation and thinning of ventricular walls is seen at 3 weeks of age

decreased heart left ventricle wall thickness ( J:126850 )

• left ventricle wall thickness is reduced

dilated heart ventricle ( J:126850 )

dilated cardiomyopathy ( J:126850 )

decreased cardiac muscle contractility ( J:126850 )

• fractional shortening is decreased

abnormal impulse conducting system conduction ( J:126850 )

• mice exhibit slowed ventricular conduction

prolonged PR interval ( J:126850 )

• PR interval is longer

• however, no arrhythmias are detected in mice

prolonged QRS complex duration ( J:126850 )

congestive heart failure ( J:126850 )

• mice die from progressive cardiac failure and not sudden death

growth/size/body

enlarged heart ( J:126850 )

• enlarged hearts with dilation of the ventricular chambers

cachexia ( J:126850 )

• before death, mice are smaller, have labored breathing and roughened fur, and are cyanotic

homeostasis/metabolism

ascites ( J:126850 )

• some mice exhibit ascites

muscle

dilated cardiomyopathy ( J:126850 )

decreased cardiac muscle contractility ( J:126850 )

• fractional shortening is decreased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:126850