Phenotypes Associated with This Genotype

Genotype
MGI:5907042

• Allelic Composition: Myocd^tm1Msp/Myocd^tm1Msp; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:154666 )

• 4 month old mice treated with tamoxifen become lethargic within 3-4 days of tamoxifen exposure and die within 7 days

cardiovascular system

abnormal myocardial fiber morphology ( J:154666 )

• derangements in cardiomyocyte structure and myofibrillar organization are seen throughout the hearts of tamoxifen-treated adult mice

• myofibrillar striations are absent in tamoxifen-treated hearts

• cardiomyocytes of tamoxifen-treated adult mice exhibit indistinct desmosomes and adherens junctions

abnormal intercalated disk morphology ( J:154666 )

• structure of the intercalated disc is disrupted in the hearts of tamoxifen-treated adult mice

myocardial fiber degeneration ( J:154666 )

• loss of cardiomyocytes in tamoxifen-treated adults

myocardial fiber disarray ( J:154666 )

• cardiomyocyte disarray with myocyte loss in hearts of tamoxifen-treated adult mice

• sparse, randomly oriented myofibers are seen throughout the sarcoplasm of hearts of tamoxifen-treated adult mice

enlarged heart ( J:154666 )

• hearts of tamoxifen-treated adult mice are enlarged

pericardial effusion ( J:154666 )

• hearts of tamoxifen-treated adult mice show large pericardial effusions

cardiac fibrosis ( J:154666 )

• fibrosis in hearts of tamoxifen-treated adult mice

dilated cardiomyopathy ( J:154666 )

• 6 days after tamoxifen treatment, adult mice exhibit severe dilated cardiomyopathy involving all 4 chambers

decreased cardiac muscle contractility ( J:154666 )

• mean ejection fraction is decreased in tamoxifen-treated adult mice

growth/size/body

enlarged heart ( J:154666 )

• hearts of tamoxifen-treated adult mice are enlarged

cellular

increased cardiomyocyte apoptosis ( J:154666 )

• widespread cardiomyocyte apoptosis in tamoxifen-treated adult mice

homeostasis/metabolism

pericardial effusion ( J:154666 )

• hearts of tamoxifen-treated adult mice show large pericardial effusions

muscle

abnormal myocardial fiber morphology ( J:154666 )

• derangements in cardiomyocyte structure and myofibrillar organization are seen throughout the hearts of tamoxifen-treated adult mice

• myofibrillar striations are absent in tamoxifen-treated hearts

• cardiomyocytes of tamoxifen-treated adult mice exhibit indistinct desmosomes and adherens junctions

abnormal intercalated disk morphology ( J:154666 )

• structure of the intercalated disc is disrupted in the hearts of tamoxifen-treated adult mice

myocardial fiber degeneration ( J:154666 )

• loss of cardiomyocytes in tamoxifen-treated adults

myocardial fiber disarray ( J:154666 )

• cardiomyocyte disarray with myocyte loss in hearts of tamoxifen-treated adult mice

• sparse, randomly oriented myofibers are seen throughout the sarcoplasm of hearts of tamoxifen-treated adult mice

dilated cardiomyopathy ( J:154666 )

• 6 days after tamoxifen treatment, adult mice exhibit severe dilated cardiomyopathy involving all 4 chambers

decreased cardiac muscle contractility ( J:154666 )

• mean ejection fraction is decreased in tamoxifen-treated adult mice

increased cardiomyocyte apoptosis ( J:154666 )

• widespread cardiomyocyte apoptosis in tamoxifen-treated adult mice

abnormal sarcomere morphology ( J:154666 )

• loss of sarcomeres in the hearts of tamoxifen-treated adult mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:154666