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Phenotypes Associated with This Genotype
Genotype
MGI:5907161
Allelic
Composition
Tg(Myh6-NEBL*G202R)#Jato/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• interstitial cell infiltration in the hearts
• increase in residual body liposome and mild variation in mitochondrial shape
• proteins in the I-band are downregulated and disrupted
• focal separation of intercalated disks
• cardiac enlargement due to left ventricle dilation
• dilation of the left ventricle as evidenced by increased left ventricle end-systolic dimensions without changes in left ventricle end-diastolic dimensions
• decrease in fractional shortening

behavior/neurological
• by 6 months of age, mice show a reduction in the tolerance against acute stress, indicated by decreased running distances compared to controls

homeostasis/metabolism
• by 6 months of age, mice show a reduction in the tolerance against acute stress, indicated by decreased running distances compared to controls

muscle
• increase in residual body liposome and mild variation in mitochondrial shape
• proteins in the I-band are downregulated and disrupted
• focal separation of intercalated disks
• decrease in fractional shortening

growth/size/body
• cardiac enlargement due to left ventricle dilation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:242962


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory