Phenotypes Associated with This Genotype

Genotype
MGI:5907886

• Allelic Composition: Tg(Myh6-HBEGF)#Iko/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:93335 )

• about 80% of mice injected intramuscularly with diphtheria toxin (DT) die within 10 days after DT injection

cardiovascular system

increased myocardial fiber size ( J:93335 )

• 1.9-fold increase in cross-sectional areas of cardiomyocytes 14 days after DT injection, indicating that cardiomyocytes which do not express the transgene and survive DT administration, undergo hypertrophic cell growth

myocardial fiber degeneration ( J:93335 )

• hearts show degenerated cardiomyocytes surrounded by inflammatory cells (macrophages) 7 days after DT injection

• myocardial cell death in DT injected mice that is primarily due to autophagy and not apoptosis

increased heart weight ( J:93335 )

• 7 days after DT injection, heart to body weight ratios are about 1.3-fold increased

cardiac interstitial fibrosis ( J:93335 )

• interstitial fibrosis in DT-treated hearts

dilated heart ( J:93335 )

• 7 days after DT injection, mice exhibit global chamber dilatation with wall thinning

dilated cardiomyopathy ( J:93335 )

decreased cardiac muscle contractility ( J:93335 )

• 7 days after DT injection, mice exhibit a 2.4-fold reduction in fractional shortening

abnormal heart echocardiography feature ( J:93335 )

• 7 days after DT injection, mice exhibit an approximate 1.3-fold increase in the left ventricular end-diastolic dimension and a 1.5-1.7-fold decrease in left ventricular wall thickness, and a 2.4-fold reduction in fractional shortening

homeostasis/metabolism

abnormal atrial thrombosis ( J:93335 )

• 7 days after DT injection, mice exhibit atrial thrombus

muscle

increased myocardial fiber size ( J:93335 )

• 1.9-fold increase in cross-sectional areas of cardiomyocytes 14 days after DT injection, indicating that cardiomyocytes which do not express the transgene and survive DT administration, undergo hypertrophic cell growth

myocardial fiber degeneration ( J:93335 )

• hearts show degenerated cardiomyocytes surrounded by inflammatory cells (macrophages) 7 days after DT injection

• myocardial cell death in DT injected mice that is primarily due to autophagy and not apoptosis

dilated cardiomyopathy ( J:93335 )

decreased cardiac muscle contractility ( J:93335 )

• 7 days after DT injection, mice exhibit a 2.4-fold reduction in fractional shortening

growth/size/body

increased heart weight ( J:93335 )

• 7 days after DT injection, heart to body weight ratios are about 1.3-fold increased

cellular

cardiac interstitial fibrosis ( J:93335 )

• interstitial fibrosis in DT-treated hearts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congestive heart failure		DOID:6000		J:93335
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:93335