Phenotypes Associated with This Genotype

Genotype
MGI:5907999

• Allelic Composition: Sod2^tm1Shs/Sod2^tm1Shs; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

myocardial fiber degeneration ( J:171017 )

• left ventricle wall shows myocardial degeneration

• treatment with EUK-8, a superoxide dismutase and catalase mimetic, diminishes myocardial degeneration

myocardial fiber disarray ( J:171017 )

• left ventricle wall shows myocyte disarray

• EUK-8 treated mice show diminished myocyte disarray

increased heart weight ( J:171017 )

• progressively increasing heart-to-body weight ratio

• treatment with EUK-8, a superoxide dismutase and catalase mimetic, decreases heart weight

cardiac interstitial fibrosis ( J:171017 )

• diffuse fibrotic scars surrounding myocardial cells

• EUK-8 treated mice show diminished fibrosis

dilated heart ( J:171017 )

• heart dilatation

dilated heart left ventricle ( J:171017 )

• increase in left ventricular end-diastolic internal dimension (LVIDd)

• EUK-8 treatment for 4 weeks decreases LVIDd

dilated cardiomyopathy ( J:171017 )

abnormal heart echocardiography feature ( J:171017 )

• increase in left ventricular end-diastolic internal dimension (LVIDd)

• EUK-8 treatment for 4 weeks decreases LVIDd

growth/size/body

increased heart weight ( J:171017 )

• progressively increasing heart-to-body weight ratio

• treatment with EUK-8, a superoxide dismutase and catalase mimetic, decreases heart weight

cellular

cardiac interstitial fibrosis ( J:171017 )

• diffuse fibrotic scars surrounding myocardial cells

• EUK-8 treated mice show diminished fibrosis

oxidative stress ( J:171017 )

• heart tissue exhibits oxidative DNA damage

• EUK-8 treatment attenuates oxidative DNA damage in heart tissue

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:171017 )

• telomerase activity is decreased in heart tissues, however telomere length is normal

• EUK-8 treatment restores normal telomerase activity

muscle

myocardial fiber degeneration ( J:171017 )

• left ventricle wall shows myocardial degeneration

• treatment with EUK-8, a superoxide dismutase and catalase mimetic, diminishes myocardial degeneration

myocardial fiber disarray ( J:171017 )

• left ventricle wall shows myocyte disarray

• EUK-8 treated mice show diminished myocyte disarray

dilated cardiomyopathy ( J:171017 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congestive heart failure		DOID:6000		J:171017
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:171017