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Phenotypes Associated with This Genotype
Genotype
MGI:5908275
Allelic
Composition
Tg(Myh6*)1Lnwd/0
Genetic
Background
involves: C57BL/6 * FVB/N
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hearts exhibit cellular hypertrophy, myocyte disorganization and small vessel pathology
• hearts exhibit myocyte disorganization
• heart mass is 40% greater than in wild-type mice at 10 months, but not 2 months of age, indicating development of cardiac hypertrophy
• hypertrophy is restricted to the left ventricle and is not seen in the right ventricle or atria
• hearts exhibit small vessel pathology, with hypertrophied vessels in 10 week old mice
• mitral valves are thickened with fibrous plaques, and frequent thrombus formation
• 1 of 6 mice show tricuspid valve pathology, involving the septal leaflet with a fibrous plaque on the right ventricular septal wall
• systolic anterior wall thickness is greater in 6 month old females
• however, no hypertrophy of the posterior wall in systole or diastole is seen
• ventricular myocytes exhibit reduced rates of relaxation after flash photolysis of diazo 2
• echocardiograms of 6 month old females indicate asymmetric anterior wall hypertrophy
• however, systolic function, as assessed by left ventricular shortening fraction, does not differ from wild-type mice
• ventricular myocytes exhibit decreased calcium sensitivity of tension

homeostasis/metabolism
• frequent thrombus formation in mitral valves

muscle
• hearts exhibit myocyte disorganization
• heart mass is 40% greater than in wild-type mice at 10 months, but not 2 months of age, indicating development of cardiac hypertrophy
• hypertrophy is restricted to the left ventricle and is not seen in the right ventricle or atria
• ventricular myocytes exhibit reduced rates of relaxation after flash photolysis of diazo 2

growth/size/body
• heart mass is 40% greater than in wild-type mice at 10 months, but not 2 months of age, indicating development of cardiac hypertrophy
• hypertrophy is restricted to the left ventricle and is not seen in the right ventricle or atria

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 14 DOID:0110320 OMIM:613251
J:55938


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory