Phenotypes Associated with This Genotype

Genotype
MGI:5908349

• Allelic Composition: Tg(Myh6*)1Lnwd/Tg(Myh6*)1Lnwd
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:55938 )

♀ • hearts exhibit more severe cellular hypertrophy, myocyte disorganization and small vessel pathology than hemizygous mice

heart left ventricle hypertrophy ( J:55938 )

abnormal coronary vessel morphology ( J:55938 )

♀ • hearts exhibit small vessel pathology

thick mitral valve ( J:55938 )

♀ • mitral valves are thickened with fibrous plaques, and frequent thrombus formation

increased heart weight ( J:55938 )

♀ • mean heart weight-to-tibia length ratio is increased in 10 month old female mice

thick ventricular wall ( J:55938 )

♀ • systolic anterior wall thickness is greater in 6 month old females

♀ • however, no hypertrophy of the posterior wall in systole or diastole is seen

abnormal heart echocardiography feature ( J:55938 )

♀ • echocardiograms of 6 month old females indicated greater anterior wall hypertrophy than in hemizygous mice

♀ • however, systolic function, as assessed by left ventricular shortening fraction, does not differ from wild-type mice

homeostasis/metabolism

abnormal cardiac thrombosis ( J:55938 )

♀ • frequent thrombus formation in mitral valves

growth/size/body

heart left ventricle hypertrophy ( J:55938 )

increased heart weight ( J:55938 )

♀ • mean heart weight-to-tibia length ratio is increased in 10 month old female mice

muscle

heart left ventricle hypertrophy ( J:55938 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrophic cardiomyopathy 14		DOID:0110320	OMIM:613251	J:55938