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Phenotypes Associated with This Genotype
Genotype
MGI:5908391
Allelic
Composition		 Orai1tm1.1Hjm/Orai1tm1.1Hjm
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 B6.Cg-Orai1tm1.1Hjm Tg(Cd4-cre)1Cwi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orai1tm1.1Hjm mutation (0 available); any Orai1 mutation (22 available)
Tg(Cd4-cre)1Cwi mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell physiology ( J:241365 )
• SOCE (store-operated Ca2+ entry) reduced by 3050% in naive CD4+ and CD8+ T cells after induction by depletion of ER Ca2+ stores with thapsigargin

immune system
abnormal T cell physiology ( J:241365 )
• SOCE (store-operated Ca2+ entry) reduced by 3050% in naive CD4+ and CD8+ T cells after induction by depletion of ER Ca2+ stores with thapsigargin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory