Phenotypes Associated with This Genotype

Genotype
MGI:5908863

• Allelic Composition: Ssu2^tm1.1Xmx/Ssu2^tm1.1Xmx
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal tooth morphology ( J:240559 )

• abnormal collagenous attachment to the gum

abnormal dental pulp cavity morphology ( J:240559 )

• narrowed dental pulp cavities

abnormal dental pulp morphology ( J:240559 )

• increased number of pulpal cells

increased odontoblast number ( J:240559 )

• significantly increased numbers of odontoblasts in the pulp cavity

abnormal dentin morphology ( J:240559 )

• increased dentin thickness

• anomalies in the number and organization of dentinal tubules

abnormal dentin mineralization ( J:240559 )

• dysplasia of the mineralized dentin

• mineralized dentin width is higher

abnormal predentin morphology ( J:240559 )

• reduced width of the predentin zone

abnormal tooth attrition ( J:240559 )

• abnormal tooth attrition whether fed normal diet or a soft diet

growth/size/body

abnormal tooth morphology ( J:240559 )

• abnormal collagenous attachment to the gum

abnormal dental pulp cavity morphology ( J:240559 )

• narrowed dental pulp cavities

abnormal dental pulp morphology ( J:240559 )

• increased number of pulpal cells

increased odontoblast number ( J:240559 )

• significantly increased numbers of odontoblasts in the pulp cavity

abnormal dentin morphology ( J:240559 )

• increased dentin thickness

• anomalies in the number and organization of dentinal tubules

abnormal dentin mineralization ( J:240559 )

• dysplasia of the mineralized dentin

• mineralized dentin width is higher

abnormal predentin morphology ( J:240559 )

• reduced width of the predentin zone

abnormal tooth attrition ( J:240559 )

• abnormal tooth attrition whether fed normal diet or a soft diet

skeleton

abnormal tooth morphology ( J:240559 )

• abnormal collagenous attachment to the gum

abnormal dental pulp cavity morphology ( J:240559 )

• narrowed dental pulp cavities

abnormal dental pulp morphology ( J:240559 )

• increased number of pulpal cells

increased odontoblast number ( J:240559 )

• significantly increased numbers of odontoblasts in the pulp cavity

abnormal dentin morphology ( J:240559 )

• increased dentin thickness

• anomalies in the number and organization of dentinal tubules

abnormal dentin mineralization ( J:240559 )

• dysplasia of the mineralized dentin

• mineralized dentin width is higher

abnormal predentin morphology ( J:240559 )

• reduced width of the predentin zone

abnormal tooth attrition ( J:240559 )

• abnormal tooth attrition whether fed normal diet or a soft diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dentin dysplasia		DOID:701	OMIM:125400 OMIM:125420	J:240559