Phenotypes Associated with This Genotype

Genotype
MGI:5910547

• Allelic Composition: Erg^tm1.1Iwamo/Erg^tm1.1Iwamo; Tg(Gdf5-cre,-ALPP)1Kng/?
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased susceptibility to induced arthritis ( J:243715 )

• 8 week old mice are more susceptible to surgically induced osteoarthritis in knees than controls

• 4 weeks post-surgery articular cartilage is eroded and the region develops ectopic chondrocyte hypertrophy and is lacking Safranin O-staining proteoglycans and lubricin

osteoarthritis ( J:243715 )

• knee articular cartilage is thin, eroded and almost absent in joints of 6-7 month old mice

• tibial plateau exhibits arthritic changes based on osteoarthritis assessment criteria

• knee joint surface of the femur exhibits arthritic changes based on osteoarthritis assessment criteria

abnormal articular cartilage morphology ( J:243715 )

• knee articular cartilage is thin, eroded and almost absent in joints of 6-7 month old mice

immune system

increased susceptibility to induced arthritis ( J:243715 )

• 8 week old mice are more susceptible to surgically induced osteoarthritis in knees than controls

• 4 weeks post-surgery articular cartilage is eroded and the region develops ectopic chondrocyte hypertrophy and is lacking Safranin O-staining proteoglycans and lubricin

osteoarthritis ( J:243715 )

• knee articular cartilage is thin, eroded and almost absent in joints of 6-7 month old mice

• tibial plateau exhibits arthritic changes based on osteoarthritis assessment criteria

• knee joint surface of the femur exhibits arthritic changes based on osteoarthritis assessment criteria

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoarthritis		DOID:8398		J:243715