mortality/aging
• mice exhibit poor survival, with females showing better survival rates than males
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• mice exhibit poor survival, with females showing better survival rates than males
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cardiovascular system
• increase in left ventricular end diastolic diameter indicating left ventricle dilation
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• the Hill coefficient is decreased in hearts, implying decreased cooperativity in muscle force generation
• 54% and 20% increases, respectively, in peak systolic and end diastolic intracellular calcium concentrations in 8 week old hearts
• hearts show a prolonged systolic rise and diastolic fall in calcium concentrations
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• dilated cardiomyopathy is evident at 6 weeks of age and persists at 12 and 30 weeks of age
• however, no myofibrillar disarray, fibrosis or apoptosis is seen in 16 week old mice
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• decrease in fractional shorting indicating reduced systolic function
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• echocardiography shows increases in left ventricular end diastolic diameter and left ventricular end systolic diameter and decreases in fractional shorting in both males and females at 6, 12, and 30 weeks of age
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• hearts exhibit a slower intrinsic sinus rhythm heart rate
• hearts exhibit lower peak heart rates in response to beta-adrenergic stimulation with isoproterenol and exposure to higher isoproterenol levels leads to sustained dysrhythmias
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• 2 of 4 mice exhibit nonsustainable polymorphic ventricular tachyarrhythmia on aggressive programmed ventricular stimulation
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• skinned fibers from hearts show reduced myofilament calcium sensitivity, without any changes in maximally activated force or length-dependent changes in calcium sensitivity
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muscle
• dilated cardiomyopathy is evident at 6 weeks of age and persists at 12 and 30 weeks of age
• however, no myofibrillar disarray, fibrosis or apoptosis is seen in 16 week old mice
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• decrease in fractional shorting indicating reduced systolic function
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nervous system
• action potential durations are shorter in hearts
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
dilated cardiomyopathy 1D | DOID:0110426 |
OMIM:601494 |
J:243725 |